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Gopu Chandran Lenin Perumal ¹, R. Mythili ², Senthil Kumar ², Subashini Suyambukesan ³

Affiliations
1 Department of Periodontology, Penang International Dental College, Penang, MY
2 Rajah Muthiah Dental College & Hospital, Annamalai University, Chidambaram, Tamilnadu, IN
3 Department of Oral medicine & Radiology, Penang International Dental College, Penang, MY

Abstract

The purpose of this study was to estimate and compare the levels of tissue non-specific alkaline phosphatase isoenzyme in serum of healthy individual and in chronic periodontitis patients with varying severity. Serum samples were obtained from 31individuals. 10 from healthy individuals and 21 from chronic periodontitis patients categorized as mild, moderate and severe based on CAL values. The samples were used to determine the Tissue Non - Specific Alkaline Phosphatase Isoenzyme (TNSALP) level. Evaluation and comparison of the tissue non - specific alkaline phosphatase isoenzyme activity between the control and chronic periodontitis patient group showed a decrease in bone type of tissue non - specific alkaline phosphatase level among mild, moderate and severe chronic periodontitis patients group. The steady decrease in Bone type of TNSALP might help to provide useful information if monitored successively over a period of time.

Keywords

Alkaline Phosphatase Isoenzyme, Chronic Periodontitis, Severity of Chronic Periodontitis, Serum Enzymatic Assay, Tissue Non-specific Alkaline Phosphatase Isoenzyme, TNSALP.

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A. Suganya ¹, A. Anand ², R. Arunadevi ³, Senthil Kumar ⁴

Affiliations
1 V.P.M.M Engg College for Women, Krishanan Koil, IN
2 R.V.S. Engg College, Dindigul, IN
3 V.P.M.M Engg College for Women, Krishanan Koil, IN
4 S.K.R Enggineering College, Chennai, IN

Abstract

The harmful disease diagnosed at early stage is the important role of the medical field. The presence of Single nucleotide polymorphism causes DNA sequence difference, affects protein changing the structure and function, which causes the human genetic disease. The technique proposed for digital coding of amino acids in DNA sequences is by combining Codons and LDPC algorithm. The existing system extract the INTRON and EXON of genome by band pass FIR filter. The past work only graphical representation that is not helpful to the medical field. Hence our work towards the digital code of DNA sequence is realizable and reliable. Innovatively, this digital code based on Codons. The Codons is useful for DNA sequence compression during the compression no noise added that is the main advantage of proposed system. This proposed work make use of information theory to set up a model of digital coding, for amino acids.. It transforms the symbolic DNA sequences into digital genetic signals. The proposed LDPC based digital coding most commonly used for error detection and correction that offer huge advantages in terms of coding gain, throughput and power dissipation. The results also provide insight into the pattern of the variations that may have a direct role in the targeted disease and can be used to improve diagnostic reliability for complex human genetic disorders. The design model is tested for several databases of Homo sapiens DNA sequence which have been downloaded from National Center for Biotechnology Information (NCBI) homepage.

Keywords

LDPC, DNA Amino Codes, Codon.

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S. Saleem Basha ¹, I. Anand Shaker ¹, Senthil Kumar ¹, K. Satya Narayana ¹, K. Suresh Babu ¹

Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), IN

Abstract

The background evidence of the association between H. pylori and peptic ucler is reviewed, together with methods of diagnosing H. pylori infection. Serological testing is considered to be simple, cheap and effective. At least one authority considers serological tests for H. pylori to be the "gold standard" against which all other should be measured. Helicobacter pylori (HP) are Gram negative spiral bacterial which occur in the muhan stomach. The bacteria were cultured in vitro for the first time in 1983, it is suspected that the bacteria may cause chronic gastritis of type B and may also be a contributory cause of chronic ulceration and cancer of the stomach. The bacteria are accompanied by characteristic inflammatory changes in the gastic mucosa. The significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcionoma of the stomach is discussed. Helicobacter pylori occurs in great proportion of the population of the world and the frequency increases with age. The route of infection is unknown but faecal-oral infection is probable. Our knowledge about the cause of peptic ulcer disease, of the aetiology of gastric cancer, and perhaps of some forms of dypepsia is in a state of revolution. The discovery of the infective organism Helicobacter pylori and its involvement in these diaseses has begun to change our views on how to approach diagnosis and treatment. Correlation between the presence of HP and occurrence of symptom is poor in the individual patient, the bacteria can be demonstrated histologically, cytological, by culture by the urease test, by the urease expiration test or serologically. The bacteria are sensitive for a series of antibiotics and bismuth but no effective treatment it known as the recurrence is high.

Keywords

Helicobacter pylori, Ulcer.

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